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DUSP12抗原(重组蛋白)

价格: 在线咨询
货号:
KT011374
产品规格:
1mg
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

中文名称:DUSP12抗原(重组蛋白)


英文名称: DUSP12 Antigen (Recombinant Protein)


储      存: 冷冻(-20℃)


相关类别: 抗原


概述

 

Fusion protein corresponding to a region derived from 1-340 amino acids of human DUSP12

 

技术规格

 

Full name:

dual specificity phosphatase 12

Synonyms:

YVH1; DUSP1

Swissprot:

Q9UNI6

Gene Accession:

BC006286

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

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