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产品详情
操作说明
注意事项
Product Information
| Description |
Chk2 mouse monoclonal |
| Protein full name |
Serine/ threonine-protein kinase Chk2 |
|
Synonyms |
CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 2 |
| Immunogen |
Recombinant protein corresponding to Mouse Chk2 |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location |
Nucleus |
| Uniprot ID |
Applications
| Applications |
IHC |
IF |
| Species |
Human |
Human |
| Dilution |
1: 300-1: 600 |
1: 150-1: 300 |
| Positive tissue |
colon, colon cancer,stomach cancer |
colon, colon cancer,stomach cancer |
Background
CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is mainly involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. When DNA undergoes a double-strand break, CHK2 is activated. Specifically, DNA damage-activated phosphatidylinositol kinase family protein (PIKK) ATM phosphorylates site Thr68 and activates CHK2. Once activated, CHK2 phosphorylates downstream targets including CDC25 phosphatases, responsible for dephosphorylating and activating the cyclin-dependent kinases (CDKs). Thus, CHK2’ s inhibition of the CDC25 phosphatases prevents entry of the cell into mitosis.
Images
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Immunohistochemistry analysis of paraffin-embedded human colon using |
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Immunohistochemistry analysis of paraffin-embedded human colon cancer |
|
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Immunohistochemistry analysis of paraffin-embedded human stomach cancer |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室