欢迎,来到万物生物官方网站!
邮箱:355185756@qq.com
全国服务热线: 400-1016-218

Anti -CyclinD1 Rabbit mAb

价格: 在线咨询
货号:
DRF101440
产品规格:
50 μL
Applications:
Species:
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description CyclinD1 Rabbit monoclonal
Protein full name G1/S-specific cyclin-D1
Synonyms B cell lymphoma 1 protein, CCND1, cyclin D1, D11S287E, G1/S specific cyclin D1, PRAD1, PRAD1 oncogene, U21B31
Immunogen Synthetic peptide within Human Cyclin D1 (C terminal). The exact sequence is proprietary
Isotype IgG
Purity Affinity purification
Subcellular location Nucleus
Uniprot ID P24385, P25322, P39948




Applications


Applications Species Dilution Positive Tissue
IHC Human, Mouse, Rat 1: 100-1: 500 kidney carcinoma, hepatocellular carcinoma




Background

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner




Images





Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

凡合肥万物生物科技有限公司销售的产品均有严格的质量保证。如发现产品存在包装规格疑问,请于收货之日起七日内向我公司总部或当地办事处提出,并请保证该产品,以备本公司进行核对检验。如果发现有质量问题,请于收货后一月内保留产品50%以上的量,以便本公司回收产品进行质检,确认产品质量。如逾期,则视为已经对本公司产品进行验收。 声明:如发生产品索赔事宜,本公司仅在产品价格范围内酌情赔偿,恕不接受超出产品价格范围之赔偿。客户在使用过程中有任何技术问题可以拨打技术售后服务电话我们随时给予解答。

合肥万物生物科技有限公司

客服热线:400-1016-218

QQ:355185756

地址:安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室

服务热线

400-1016-218

功能和特性

价格和优惠

获取新资料

售后服务

咨询微信