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产品详情
操作说明
注意事项
Product Information
|
Description |
CD86 rabbit monoclonal |
|
Protein full name |
CD86 |
|
Synonyms |
Activation B7-2 antigen, CD28LG2, CTLA-4 counter-receptor B7.2 2 |
|
Immunogen |
Monoclonal antibody is produced by immunizing animals with mouse CD86 recombinant protein. |
|
Isotype |
IgG |
|
Purity |
Protein A purified |
|
Subcellular location |
Membrane |
|
Predicted MW. |
60Da |
|
Observed MW. |
85 kDa |
|
Uniprot ID |
P42082 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Mouse |
1: 100-1: 400 |
liver, lung |
|
IF |
Mouse |
1: 100-1: 400 |
liver, lung |
Background
CD80 (B7-1, BB1) and CD86 (B7-2, B70) are members of the B7 family of cell surface ligands that regulate T cell activation and immune responses. CD80 is expressed on activated antigen presenting cells, including dendritic cells, B cells, monocytes, and macrophages. CD86 is expressed on resting monocytes, dendritic cells, activated B lymphocytes, and can be further upregulated in the presence of inflammation (1-3). CD80 and CD86 are ligands for CD28, which functions as a T cell costimulatory receptor. Interaction of CD28 with CD80 or CD86 provides the second signal required for naïve T cell activation, T cell proliferation, and acquisition of effector functions (3-7). Alternatively, CD80 and CD86 also act as ligands to CTLA-4, which results in the downregulation of T cell activity (3,7-9).
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室