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Product Information
| Description | E-cadherin mouse polyclonal |
| Protein full name | Epithelial cadherin |
| Synonyms | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin 1, BCDS1 |
| Immunogen | Synthesized peptide derived from human E-Cadherin |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Cell membrane |
| Uniprot ID | P12830 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| IHC、IF | Human | 1: 200-1: 500 | brain, epidermal carcinoma, hippocampus, liver, pancreas, placenta |
Background
cadherin 1(CDH1) Homo sapiens This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
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