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产品详情
操作说明
注意事项
Product Information
|
Description |
MCP1 rabbit polyclonal |
|
Protein full name |
C-C motif chemokine 2 |
|
Synonyms |
CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2, MCP-1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Human MCP1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
11 kDa |
|
Observed MW. |
11 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human |
1: 500-1: 1000 |
THP-1 |
Background
Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, monocyte chemotactic activating factor (MCAF) or glioma-derived chemotactic factor-2 (GDCF-2), is the product of the human JE gene and a member of the family of C-C (or β) chemokines . The predicted molecular weight of MCP-1 protein is 11-13 kDa, but it may migrate at 20-30 kDa due to glycosylation. MCP-1 is secreted by a variety of cell types in response to pro-inflammatory stimuli and was originally described for its chemotactic activity on monocytes. This activity has led to studies demonstrating its role in diseases characterized by monocyte infiltrates such as psoriasis , rheumatoid arthritis and atherosclerosis . MCP-1 may also contribute to tumor progression and angiogenesis . Signaling by MCP-1 is mediated by the G-protein coupled receptor CCR2 .
Images
|
Western blot analysis of MCP1 (GB113239) at dilution of 1: 1000 Lane 1: THP-1 untreated Lane 2: THP-1 treated with 80nM TPA for 24h Lane 3: THP-1 treated with 80nM TPA for 24h, then treated with 100ng/ml lipopolysaccharide (LPS) for 6h, then with 300ng/ml Brefeldin A added after 3 hours, whole cell lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
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地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室