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Anti -CD8 Rabbit pAb

价格: 在线咨询
货号:
DRF101783
产品规格:
50 μL
Applications:
Species:
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description CD8 rabbit polyclonal
Protein full name T-cell surface glycoprotein CD8 alpha chain
Synonyms CD8A, CD8, Leu2, MAL, p32,CD8a molecule, CD8 alpha
Immunogen Synthetic peptide within Human CD8 aa 200 to the C-terminus. The exact sequence is proprietary.
Isotype IgG
Purity Affinity purification
Subcellular location Cell membrane, Secreted
Uniprot ID P01732




Applications


Applications Species Dilution Positive Tissue
IHC Human 1: 200-1: 400 tonsil




Background

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.




Images





Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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