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Anti -CD163 Rabbit pAb

价格: 在线咨询
货号:
DRF101796
产品规格:
100 μL
Applications:
Species:
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information



Description CD163 rabbit polyclonal
Protein full name Scavenger receptor cysteine-rich type 1 protein M130

Synonyms

CD163, M130, MM130, SCARI1, CD163 molecule
Immunogen

Recombinant protein corresponding to  Mouse CD163

Isotype IgG
Purity Affinity purification
Subcellular location

Secreted,Cell membran

Uniprot ID

Q2VLH6




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1:200-1:1000

spleen

IF

Mouse, Rat

1:200-1:1000

spleen




Background



Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity).




Images



image.png

Immunohistochemistry analysis of paraffin-embedded mouse spleen using CD163 (GB11340-1) at dilution of 1:300


image.png

Immunohistochemistry analysis of paraffin-embedded mouse Inflammatory spleen using CD163 (GB11340-1) at dilution of 1:500


image.png

Immunohistochemistry analysis of paraffin-embedded rat Inflammatory spleen using CD163 (GB11340-1) at dilution of 1:300





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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