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Anti -GPX1 Rabbit pAb

价格: 在线咨询
货号:
KT011481
产品规格:
Applications:
WB
Species:
M,R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

GPX1 rabbit polyclonal antibody

Protein full name

Glutathione peroxidase 1

Synonyms

GPX1, GPXD, GSHPX1, glutathione peroxidase 1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse GPX1

Isotype

IgG

Purity

Affinity purification

Predicted MW.

22 kDa

Observed MW.

22 kDa

Uniprot ID

P11352, P04041



Applications


applications

species

dilution

Positive tissue

WB

Mouse, Rat

1: 500-1: 1000

liver, spleen, kidney




Background


As a glutathione peroxidase, GPx1 functions in the detoxification of hydrogen peroxide, specifically by catalyzing the reduction of hydrogen peroxide to water. The glutathione peroxidase also catalyzes the reduction of other organic hydroperoxides, such as lipidperoxides, to the corresponding alcohols.GPx1 typically uses glutathione (GSH) as the reductant, but when glutathione synthetase (GSS) is, as in brain mitochondria, γ-glutamylcysteine can serve as the reductant instead.The protein encoded by this gene protects from CD95-induced apoptosis in cultured breast cancer cells and inhibits 5-lipoxygenase in blood cells, and its overexpression delays endothelial cell death and increases resistance to toxic challenges, especially oxidative stress.This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA.

   



Images



Picture 1.png

Western blot analysis of GPX1 (GB11291) at dilution of 1: 500




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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