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Anti -RAGE Rabbit pAb

价格: 在线咨询
货号:
KT011559
产品规格:
100 μL
Applications:
WB
Species:
HMR
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

RAGE rabbit polyclonal antibody

Protein full name

Receptor for advanced glycatio endproducts

Synonyms

AGER, Ager, RAGE, SCARJ1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse RAGE

Isotype

IgG

Purity

Affinity purification

Subcellular location

Secreted, Cell membrane

Predicted MW.

43 kD

Observed MW.

48 kD

Uniprot ID

Q62151, Q15109, Q63495



Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

lung




Background


Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.




Images



Picture 1.png

Western blot analysis of RAGE (GB11278) at dilution of 1: 500




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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