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Anti -Amyloid beta precursor protein Rabbit pAb

价格: 在线咨询
货号:
KT011562
产品规格:
100 μL
Applications:
WB/IHC/IF
Species:
HMR/MR/MR
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

Amyloid beta precursor protein

rabbit polyclonal

Protein full name

Amyloid beta A4 protein

Synonyms

APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, amyloid beta precursor protein, preA4, β-Amyloid

Immunogen

Recombinant protein corresponding to

Mouse Amyloid beta precursor protein (APP)

Isotype

IgG

Purity

Affinity purification

Subcellular location

Membrane

Predicted MW.

86 kDa

Observed MW.

100-140 kDa

Uniprot ID

P12023P08592



Applications



Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 300-1: 800

brain, cerebellum

IHC

Mouse, Rat

1: 500-1: 1000

brain

IF

Mouse, Rat

1: 500-1: 1000

brain

Background


Functions as a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis. 




Images




Western blot analysis of APP(GB11307) at dilution of 1: 800

Western blot analysis of APP(GB11307) at dilution of 1: 800
图片 12.png

Immunohistochemistry analysis of paraffin-embedded mouse brain using 

APP(GB11307) at dilution of 1: 500

图片 13.png

Immunohistochemistry analysis of paraffin-embedded rat brain using 

APP(GB11307) at dilution of 1: 500




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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