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Anti -Phospho-TAU (S202/T205) Rabbit pAb

价格: 在线咨询
货号:
KT011642
产品规格:
100 μL
Applications:
WB/IHC/IF
Species:
HMR/HMR
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information



Description

Phospho-TAU (S202/T205) rabbit polyclonal antibody

Protein full name

Microtubule-associated protein tau

Synonyms

Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU, P-TAU

Immunogen

KLH conjugated Synthetic phosphopeptide corresponding to Human TAU (S202/T205)

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Cytoskeleton, Secreted, Cell membrane, Cell projection

Predicted MW.

79 kDa

Observed MW.

50-80 kDa

Uniprot ID

P10636-8





Applications



Applications

Species

Dilution

Positive Sample

WB

Human, Mouse, Rat

1: 500-1: 1000

brain, hippocampus, liver, spleen

IHC/IF

Human, Mouse, Rat

1: 600-1: 1200

brain





Background


Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity .The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both .Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.




Images


图片 1.png Western blot analysis of phospho-TAU (S202/T205) (GB113883) at dilution of 1: 1000
图片 2.png Western blot analysis of phospho-TAU (S202/T205) (GB113883) at dilution of 1: 1000 The figure above was treated with phospho-blocking pepide, the figure below was treated with non-phospho- blocking pepide.
图片 3.png Immunohistochemistry of paraffin embedded mouse brain using phospho-TAU (S202/T205)  at dilution of 1: 1200




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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