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产品详情
操作说明
注意事项
Product Information
|
Description |
TrkB rabbit polyclonal |
|
Protein full name |
BDNF/NT-3 growth factors receptor |
|
Synonyms |
NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD |
|
Immunogen |
Recombinant protein corresponding to Mouse TrkB |
|
Isotype |
IgG |
|
Subcellular location |
|
|
Purity |
Affinity purification |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Mouse, Rat |
1: 500-1: 4000 |
brain, spinal marrow |
|
IF |
Mouse, Rat |
1: 500-1: 1000 |
brain, spinal marrow |
Background
Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), andneurotrophin-3 (NT-3). As such, TrkB mediates the multiple effects of these neurotrophic factors, which includes neuronal differentiation and survival. Research has shown that activation of the TrkB receptor can lead to down regulation of the KCC2 chloride transporter in cells of the CNS.
Images
|
Immunohistochemistry analysis of paraffin-embedded rat brain using TrkB (GB11295-2) at dilution of 1: 500 |
|
Immunohistochemistry analysis of paraffin-embedded mouse brain using TrkB (GB11295-2) at dilution of 1: 500 |
|
Immunohistochemistry analysis of paraffin-embedded mouse spinal marrow using TrkB (GB11295-2) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室