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Anti -MDA5 Rabbit pAb

价格: 在线咨询
货号:
DRF101745
产品规格:
100 μL
Applications:
Species:
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

MDA5 rabbit polyclonal

Protein full name

Interferon-induced helicase C domain-containing protein 1

Synonyms

Helicase with 2 CARD domains, Helicard, Melanoma differentiation-associated protein 5, MDA-5, RIG-I-like receptor 2, RLR-2, Ifih1, RH116, MDA5

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse MDA5

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Nucleus

Uniprot ID

Q8R5F7




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 300-1: 600

liver, kidney, heart

IF

Mouse, Rat

1: 300-1: 600

lung, kidney longitudinal




Background


IFIH1 (Interferon-induced helicase C domain-containing protein 1) is a putative RNA helicase that is upregulated in response to treatment with IFNB or IFNB and MEZ. It is also named as MDA5 and RH116. Ectopic expression of MDA5 in melanoma cells resulted in reduced colony formation, suggesting an interaction of the CARD and apoptotic signal molecules. Functional analysis indicated that MDA5 is an RNA-dependent ATPase. IFIH1 has an apparent molecular mass of 117-130 kDa, and always other bands (70 kDa and 90 kDa) can be detected as cleaved products.




Images


Immunohistochemistry analysis of paraffin-embedded mouse liver using

MDA5 (GB111891) at dilution of 1: 600

Immunohistochemistry analysis of paraffin-embedded mouse kidney using

MDA5 (GB111891) at dilution of 1: 600

Immunohistochemistry analysis of paraffin-embedded mouse heart using

MDA5 (GB111891) at dilution of 1: 600

Immunofluorescent analysis of paraformaldehyde-fixed mouse lung using

MDA5 (GB111891) at dilution of 1: 600

Immunofluorescent analysis of paraformaldehyde-fixed mouse kidney longitudinal using 

MDA5 (GB111891) at dilution of 1: 600




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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