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Anti -Bub3 Rabbit pAb

价格: 在线咨询
货号:
KT011733
产品规格:
Applications:
Species:
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

Bub3 rabbit polyclonal antibody

Protein full name

Mitotic checkpoint protein BUB3

Synonyms

WD repeat type I transmembrane protein A72.5, Bub3

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Bub3

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

O43684, Q9WVA3




Applications


Applications

Species

Dilution

Positive Sample

IHC/IF

Human, Mouse, Rat

1: 500-1: 3000

brain, breast cancer, lung, lung cancer, pancreas, small intestine, thyroid gland




Background


Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20.




Images


Picture 1.png

Immunohistochemistry of paraffin embedded human breast cancer using BuB3 (GB111183) at dilution of 1:1400 (400x lens)

Picture 2.png

Immunohistochemistry of paraffin embedded human lung cancer using BuB3 (GB111183) at dilution of 1:1400 (400x lens)

Picture 3.png

Immunohistochemistry of paraffin embedded human thyroid gland using BuB3 (GB111183) at dilution of 1:1400 (400x lens)

Picture 4.png

Immunohistochemistry of paraffin embedded mouse lung using BuB3 (GB111183) at dilution of 1:1400 (400x lens)

Picture 5.png

Immunohistochemistry of paraffin embedded mouse pancreas using BuB3 (GB111183) at dilution of 1:1400 (400x lens)

Picture 6.png

Immunohistochemistry of paraffin embedded rat brain using BuB3 (GB111183) at dilution of 1:1400 (400x lens)

Picture 7.png

Immunohistochemistry of paraffin embedded rat lung using BuB3 (GB111183) at dilution of 1:1400 (400x lens)

Picture 8.png

Immunofluorescence of paraffin embedded human breast cancer using BuB3 (GB111183) at dilution of 1:1300 (400x lens)

Picture 9.png

Immunofluorescence of paraffin embedded mouse brain using BuB3 (GB111183) at dilution of 1:1300 (400x lens)

Picture 10.png

Immunofluorescence of paraffin embedded rat pancreas using BuB3 (GB111183) at dilution of 1:1300 (400x lens)

Picture 11.png

Immunofluorescence of paraffin embedded rat small intestine using BuB3 (GB111183) at dilution of 1:1300 (400x lens)




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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