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Anti -CollagenI Rabbit pAb

价格: 在线咨询
货号:
KT011823
产品规格:
100ul
Applications:
WB/IHC/IF
Species:
H/M/R,H/M/R,H/M/R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

Collagen I rabbit polyclonal

Protein full name

Collagen alpha-1(I) chain

Synonyms

COL1A1, EDSC, OI1, OI2, OI3, OI4, collagen type I alpha 1, collagen type I alpha 1 chain

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse COL1A1 

Isotype

IgG

Purity

Affinity purification

Predicted MW.

138 kDa

Observed MW.

120 kDa

Uniprot ID

P02452P11087P02454



Applications


applications

species

dilution

Positive tissue

WB

Human, 

Mouse, Rat

1: 500-1: 1000

skin, uterus, lung, cartilage

IHC

Human, 

Mouse, Rat

1: 200-1: 1700

lung, skin

IF

Human, 

Mouse, Rat

1: 100-1: 1000

lung, skin



Background

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. 




Images


Western blot analysis of Collagen I (GB11022) at dilution of 1: 2000

Lane 1: MCF-7 cell lysate

Lane 2: Mouse cartilage tissue lysate

Lane 3: Mouse skin tissue lysate

Lane 4: Mouse uterus tissue lysate

Lane 5: Rat cartilage tissue lysate

Lane 6: Rat lung tissue lysate

Lane 7: Rat skin tissue lysate


Immunohistochemistry analysis of paraffin-embedded mouse lung using Collagen I (GB11022) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded rat lung using Collagen I (GB11022) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded rat skin using Collagen I (GB11022) at dilution of 1: 2000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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