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Anti -CDKN2A/p16INK4a Rabbit pAb

价格: 在线咨询
货号:
KT011828
产品规格:
100 μL
Applications:
WB
Species:
H
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

CDKN2A/p16INK4a rabbit polyclonal antibody

Protein full name

Cyclin-dependent kinase inhibitor 2A

Synonyms

Cyclin-dependent kinase 4 inhibitor A, CDK4I, CDKN2A, MTS1, CDKN2 , Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16INK4A, p16-INK4

Immunogen

KLH conjugated Synthetic peptide corresponding to Human CDKN2A/p16INK4a

Isotype

IgG

Purity

Affinity purification

Predicted MW.

17 kDa

Observed MW.

17 kDa

Uniprot ID

P42771




Applications


Applications

Species

Dilution

Positive Sample

WB

Human

1: 500-1: 1000

HeLa, Saso-2, 293T, HepG2, HEK293




Background


This gene generates several transcript variants which differ in their first exons.There are at least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon and this transcript contains an alternate open reading frame (ARF) that  ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.




Images


Picture 1.png

Western blot analysis of p16 (GB111605) at dilution of 1: 500




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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