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Anti -P35 Rabbit pAb

价格: 在线咨询
货号:
KT011836
产品规格:
100 μL
Applications:
WB
Species:
M,R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

P35 rabbit polyclonal antibody

Protein full name

Cyclin-dependent kinase 5 activator 1

Synonyms

CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit, Tau protein kinase II 23 kDa subunit, Cdk5r1, CDK5P35, Neuronal CDK5 activator

Immunogen

Recombinant protein corresponding to Mouse P35

Isotype

IgG

Purity

Affinity purification

Predicted MW.

34 kDa

Observed MW.

35 kDa

Uniprot ID

P61809, P61810




Applications


Applications

Species

Dilution

Positive Sample

WB

Mouse, Rat

1: 500-1: 1000

hippocampus, brain, spinal cord, cerebellum




Background


Cyclin dependent kinase-5 (Cdk5), is an atypical but essential member of the Cdk family of proline-directed serine/threonine kinases. CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays a central role in neuronal migration and differentiation during central nervous system development. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form.The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location.




Images


Western blot analysis of P25 (GB111614) at dilution of 1: 500


Western blot analysis of P35 (GB111614) at dilution of 1: 500




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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