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Anti -Kir6.2/BIR Rabbit pAb

价格: 在线咨询
货号:
KT011989
产品规格:
100 μL
Applications:
WB
Species:
MR
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

Kir6.2 rabbit polyclonal antibody

Protein full name

ATP-sensitive inward rectifier potassium channel 11

Synonyms

Inward rectifier K(+) channel Kir6.2, Potassium channel, Kcnj11, inwardly rectifying subfamily J member 11

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Kir6.2

Isotype

IgG

Purity

Affinity purification

Predicted MW.

44 kDa

Observed MW.

44 kDa

Uniprot ID

Q61743, P70673




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

heart, brain



Background


Kir6.2 (also known as BIR or IKATP), encoded by the KCNJ11 gene, is the pore-forming unit of the ATP-sensitive K+ channel, an inward-rectifier potassium ion channel. Kir6.2 is controlled by G-proteins and is found associated with the sulfonylurea receptor (SUR) to constitute the ATP-sensitive K+ channel. The KCNJ11 gene is located at 11p15.1 and has no intron. Mutations in KCNJ11 are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in KCNJ11 may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM).




Images


Picture 1.png

Western blot analysis of KCN11 (GB111084) at dilution of 1: 500




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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