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Anti -CARM1 Rabbit pAb

价格: 在线咨询
货号:
KT011990
产品规格:
100ul
Applications:
IHC/IF
Species:
M/R,M/R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

CARM1 rabbit polyclonal

Protein full name

Histone-arginine methyltransferase CARM1

Synonyms

Prmt4, Protein arginine N-methyltransferase 4, PRMT 4, Coactivator-associated arginine methyltransferase 1, Carm1

Immunogen

Recombinant protein corresponding to Mouse CARM1

Isotype

IgG

Purity

Affinity purification

Subcellular location

CytoplasmNucleus

Uniprot ID

Q9WVG6Q4AE70




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 800-1: 2000

brain

IF

Mouse, Rat

1: 400-1: 800

brain




Background


CARM1, also named as PRMT4, belongs to the protein arginine N-methyltransferase family. It is a dual functional coregulator that facilitates transcription initiation by methylation of Arg17 and Arg26 of histone H3 and also dictates the subsequent coactivator complex disassembly by methylation of the steroid receptor coactivator family coactivators and p300/cAMP-response element-binding protein. CARM1 functions as a coactivator for many nuclear receptors, such as oestrogen receptor, androgen receptor, thyroid receptor and farnesoid X-receptor. It also coactivates other transcription factors such as myocyte enhancer factor 2C (MEF2C), β-catenin, p53, nuclear factor (NF)-kB and the cAMP-responsive element-binding factor. The enzymatic activity and coactivator function of CARM1 has been found to be inactivated through phosphorylation at a conserved serine residue at mitosis stage.




Images


image.png

Immunohistochemistry analysis of paraffin-embedded mouse brain using CARM1 (GB111036) at dilution of 1: 1000

image.png

Immunohistochemistry analysis of paraffin-embedded rat brain using CARM1 (GB111036) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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