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Anti -EGFR Rabbit pAb

价格: 在线咨询
货号:
KT012045
产品规格:
100ul
Applications:
WB
Species:
H
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

EGFR rabbit polyclonal antibody

Protein full name

Epidermal growth factor receptor

Synonyms

EGFR, ERBB, ERBB1, HER1, NISBD2, PIG61, mENA, epidermal growth factor receptor

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse EGFR

Isotype

IgG

Purity

Affinity purification

Predicted MW.

134 kDa

Observed MW.

175 kDa

Uniprot ID

Q01279, P00533




Applications


Applications

Species

Dilution

Positive Sample

WB

Human

1: 600-1: 1000

HepG2, A549, A431, Hacat, Hct116




Background



Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules.

       



Images



Picture 1.png

Western blot analysis of EGFR (GB11084-1) at dilution of 1: 600




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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