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Anti -Constitutive androstane receptor Rabbit pAb

价格: 在线咨询
货号:
KT012075
产品规格:
100ul
Applications:
WB|IHC/IF
Species:
M/R,M/R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

Nr1i3 rabbit polyclonal antibody

Protein full name

Nuclear receptor subfamily 1 group I member 3

Synonyms

Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, Nr1i3, Car, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3

Immunogen

Recombinant protein corresponding to Mouse Nr1i3

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus, Cytoplasm

Predicted MW.

41 kDa

Observed MW.

41 kDa

Uniprot ID

O35627, Q9QUS1




Applications


Applications

Species

Dilution

Positive Sample

WB

Mouse, Rat

1: 500-1: 1000

liver

IHC/IF

Mouse, Rat

1: 500-1: 1000

hepatitis




Background


This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription.




Images



Western blot analysis of NR1I3 (GB111418) at dilution of 1: 500

Immunohistochemistry of paraffin embedded mouse hepatitis using NR1I3 (GB111418) at dilution of 1: 500 (200x lens)

Immunohistochemistry of paraffin embedded rat hepatitis using NR1I3 (GB111418) at dilution of 1: 500 (200x lens)




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).


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