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产品详情
操作说明
注意事项
Product Information
|
Description |
LC3A/B rabbit polyclonal antibody |
|
Protein full name |
Microtubule-associated proteins 1A/1B light chain 3 |
|
Synonyms |
LC3, LC3A, LC3A/B, LC3B, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, MAP1ALC3, MAP1BLC3, MAP1LC3A, MAP1LC3A/B, MAP1LC3B |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse LC3B |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
14/16 kDa |
|
Observed MW. |
14/16 kDa |
|
Uniprot ID |
Q9GZQ8,Q9H492,Q62625,Q6XVN8,Q9CQV6,Q91VR7 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
WB |
Human, Mouse, Rat |
1: 1000-1: 2000 |
brain, lung |
Background
LC3, also known as microtubule-associated protein 1 light chain 3 (MAP1LC3), is a mammalian homolog of the yeast Atg8p (autophagy-related 8 protein) that is involved in autophagy process. Three isoforms of LC3 exist as LC3A,LC3B, and LC3C. LC3 is first synthesized as pro-LC3, and undergoes C-terminal cleavage to yield a cytosolic precursor known as LC3-I. During autophagy LC3-I is subsequently conjugated to PE lipid as lipidated form: LC3-II. The lipidated form migrates faster on SDS-PAGE gel. The increased the level of LC3-II has been widely used as autophagy marker. This antibody recognizes both LC3-I and LC3-II.
Images
|
|
Western blot analysis of LC3AB (GB11124) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室