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Anti -Caspase-3 Rabbit pAb

价格: 在线咨询
货号:
KT012186
产品规格:
100ul
Applications:
IHC/IF
Species:
H/R,H/R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

Caspase-3 rabbit polyclonal

Protein full name

Caspase-3

Synonyms

Casp3, CASP3, CPP32, CPP32B, SCA-1, Caspase 3

Immunogen

Recombinant protein corresponding to Mouse Caspase3

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm

Uniprot ID

P42574, P70677, P55213



Applications


Applications

Species

Dilution

Positive Tissue

IHC 

Human, Rat

1: 100-1: 200

breast cancer, liver cancer, colon cancer

IF

Human, Rat

1: 100-1: 200

breast cancer, liver cancer, colon cancer



Background


Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.




Images



图片 4.png

Immunohistochemistry analysis of paraffin-embedded human breast cancer using Caspase-3 (GB11009-1) at dilution of 1: 200

图片 5.png

Immunohistochemistry analysis of paraffin-embedded human liver cancer using Caspase-3 (GB11009-1) at dilution of 1: 200

图片 6.png

Immunohistochemistry analysis of paraffin-embedded human colon cancer using Caspase-3 (GB11009-1) at dilution of 1: 200




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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