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Anti -EGFR Rabbit pAb

价格: 在线咨询
货号:
DRF101100
产品规格:
100 μL
Applications:
WB
Species:
H/M/R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information



Description EGFR rabbit polyclonal
Protein full name Epidermal growth factor receptor

Synonyms

EGFR, ERBB, ERBB1, HER1, NISBD2, PIG61, mENA, epidermal growth factor receptor

Immunogen KLH conjugated Synthetic peptide corresponding to Mouse EGFR
Isotype IgG
Purity Affinity purification
Predicted MW. 134KDa
Observed MW. 175KDa
Uniprot ID

P00533,Q01279




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1:500-1:1000

HepG2,A549,A431,Hacat,Hct116




Background



Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules.

       



Images



blob.png

Western blot analysis of EGFR (GB11084-2) at dilution of 1:1000.

Lane 1:HepG2 cell lysate

Lane 2:A549 cell lysate

Lane 3:MCF-7 cell lysate

Lane 4:Mouse lung tissue lysate

Lane 5:Mouse colon tissue lysate

Lane 6:Mouse skin tissue lysate

Lane 7:Rat lung tissue lysate

Lane 8:Rat colon tissue lysate

Lane 9:Rat skin tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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