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Anti -Neurofibromin Rabbit pAb

价格: 在线咨询
货号:
DRF101236
产品规格:
100 μL
Applications:
WB/IHC/IF
Species:
H/M/R,H/M/R,H/M/R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

Neurofibromin rabbit polyclonal

Protein full name

Neurofibromin

Synonyms

Neurofibromatosis-related protein NF-1, Nf1, Neurofibromin, neurofibromin 1, NFNS, VRNF, WSS

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Neurofibromin

Isotype

IgG

Purity

Affinity purification

Predicted MW.

320 kDa

Observed MW.

320 kDa

Subcellular location

Nucleus

Uniprot ID

P21359, Q04690, P97526




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

lung

IHC

Human, Mouse, Rat

1: 1500-1: 4000

brain, lung, kidney, colon, testis, ovary

IF

Human, Mouse, Rat

1: 750-1: 1500

brain, lung, kidney, colon, testis, ovary




Background


Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity. Besides JMML, defects in NF1 have also been linked to neurofibromatosis type 1 (NF1), Watson syndrome (WS), familial spinal neurofibromatosis (FSNF), neurofibromatosis-Noonan syndrome (NFNS), colorectal cancer (CRC).




Images


Western blot analysis of Neurofibromin (GB111112) at dilution of 1: 1000
Lane 1: Hela cell lysate
Lane 2: Mouse lung tissue lysate
Lane 3: Rat lung tissue lysate

Immunohistochemistry analysis of paraffin-embedded mouse brain using Neurofibromin (GB111112) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded mouse lung using Neurofibromin (GB111112) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded rat kidney using Neurofibromin (GB111112) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded mouse colon using Neurofibromin (GB111112) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded mouse testis using Neurofibromin (GB111112) at dilution of 1: 3000

Immunohistochemistry analysis of paraffin-embedded rat ovary using Neurofibromin (GB111112) at dilution of 1: 2000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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