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产品详情
操作说明
注意事项
Product Information
|
Description |
N Cadherin rabbit polyclonal |
|
Protein full name |
Cadherin-2 |
|
Synonyms |
Neural cadherin, N-cadherin, CD325, CDw325, Cadherin 2 N cadherin neuronal, CDHN, Cdh2, Cadherin 2 type 1, NCAD, N cadherin 1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse N Cadherin |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
100 kDa |
|
Observed MW. |
140 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
muscle, testis |
Background
N-cadherin (neuronal cadherin; or CDH2/cadherin 2) is a calcium-binding, single pass transmembrane cell adhesion molecule (CAM) that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
Images
|
Western blot analysis of N Cadherin (GB111009) at dilution of 1: 1000 Lane 1: A549 cell lysate Lane 2: MCF7 cell lysate Lane 3: SKOV3 cell lysate Lane 4: Mouse muscle tissue lysate Lane 5: Mouse testis tissue lysate Lane 6: Rat muscle tissue lysate Lane 7: Rat testis tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
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地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室