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Anti -Polycystin 1/PC1 Rabbit pAb

价格: 在线咨询
货号:
DRF101134
产品规格:
100 μL
Applications:
WB
Species:
H
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

Polycystin 1 rabbit polyclonal

Protein full name

Polycystin-1

Synonyms

PC1, Autosomal dominant polycystic kidney disease 1 protein, PKD1, PBP, PKD, PKD1, Polycystin 1 Precursor

Immunogen

Recombinant protein corresponding to Mouse Polycystin 1

Isotype

IgG

Purity

Affinity purification

Predicted MW.

463 kDa

Observed MW.

>460 kDa

Uniprot ID

P98161




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human

1: 500-1: 1000

HEK293, NIH/3t3, PC12, HCT116, SW480




Background


This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. Involved in renal tubulo genesis. Involved in fluid-flow mechano sensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene.




Images


image.png

Western blot analysis of Polycystin 1 (GB111019) at dilution of 1: 800

Lane 1: HEK293 cell lysate

Lane 2: NIH/3t3 cell lysate

Lane 3: PC12 cell lysate

Lane 4: HCT116 cell lysate

Lane 5: SW480 cell lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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