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Anti -14-3-3 zeta Rabbit pAb

价格: 在线咨询
货号:
DRF101139
产品规格:
100 μL
Applications:
WB/IHC/IF
Species:
H/M/R,M/R,M/R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

14-3-3 zeta rabbit polyclonal

Protein full name

14-3-3 protein zeta/delta

Synonyms

Protein kinase C inhibitor protein 1, KCIP-1, SEZ-2, Ywhaz, 14-3-3 Delta, 14-3-3 Zeta

Immunogen

Recombinant protein corresponding to

Mouse 14-3-3 zeta

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm

Predicted MW.

28 kDa

Observed MW.

28 kDa

Uniprot ID

P63104, P63101, P63102




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

lung, kidney, brain

IHC

Mouse, Rat

1: 1000-1: 2000

brain

IF

Mouse, Rat

1: 500-1: 1000

brain




Background


YWHAZ belongs to the 14-3-3 family of proteins which are in charge for checkpoint control, apoptotic & nutrient sensing pathways as well as signal transduction by binding to phosphoserine-containing proteins. This highly conserved and ubiquitously expressed protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. It interacts with IRS1 protein,signifying a role in regulating insulin. YWHAZ function as an adapter protein involved in the regulation of a large spectrum of both general and specialized signaling pathway. YWHAZ binds to a large number of partners,usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.




Images


image.png

Western blot analysis of 14-3-3 zeta (GB111023) at dilution of 1: 1000

Lane 1: Hela cell lysate

Lane 2: HepG2 cell lysate

Lane 3: SH-SY5Y cell lysate

Lane 4: Mouse lung tissue lysate

Lane 5: Mouse kidney tissue lysate

Lane 6: Mouse brain tissue lysate

Lane 7: Rat lung tissue lysate

Lane 8: Rat kidney tissue lysate

Lane 9: Rat brain tissue lysate

image.png

Immunohistochemistry analysis of paraffin-embedded mouse brain using 14-3-3 zeta (GB111023) at dilution of 1: 2000

image.png

Immunohistochemistry analysis of paraffin-embedded rat brain using 14-3-3 zeta (GB111023) at dilution of 1: 2000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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