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Anti -NFAT4/NF-ATc3 Rabbit pAb

价格: 在线咨询
货号:
DRF101144
产品规格:
100 μL
Applications:
IHC/IF
Species:
H,H
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

NFAT4/NF-ATc3 rabbit polyclonal

Protein full name

Nuclear factor of activated T-cells, cytoplasmic 3

Synonyms

NFATc3, NFATx, T-cell transcription factor NFAT4, NF-AT4, NF-AT4c, NFATC3

Immunogen

Recombinant protein corresponding to

Mouse NFAT4/NF-ATc3

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Nucleus

Uniprot ID

Q12968




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human

1: 500-1: 2000

colon cancer

IF

Human

1: 250-1: 500

colon cancer




Background


NFATC3  (nuclear factors of activated T cells) proteins are a family of transcription factors originally identified as mediators of activation of cytokine genes in response to antigenic stimulation of T cells.NFATC3 is widely expressed being found in DP thymocytes, CD4+ T cells, smooth muscle cells, Schwann cells and mast cells. NFATC3 regulates gene transcription as part of a NFATC transcription complex. It is normally cytoplasmic and phosphorylated. Upon a rise in intracellular Ca+2, dephosphorylation occurs via calcineurin, and NFATC3 enters the nucleus. Human NFATC3 is 1075 amino acids in length. It contains a calcineurin binding site (aa 109‑114), two nuclear localization sites (aa 273‑275 and 686‑688), one nuclear export site (a 1032‑1041) and an RH domain that binds DNA (aa 433‑592). There are multiple isoforms with different tissue expression profiles. Over a 900‑1035, human NFATC3 shares 93% a identity with mouse NFATC3. The calculated molecular weight of NFATC3 is 115 kDa, but the post-modified protein is about 130-170 kDa .




Images


image.png

Immunohistochemistry analysis of paraffin-embedded human colon cancer using NFAT4/NF-ATc3 (GB111028) at dilution of1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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