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Anti -Topoisomerase II alpha Rabbit pAb
价格：
在线咨询
货号：
DRF101148
产品规格：
100 μL
Applications：
IHC/IF
Species：
M/R,M/R
购买数量：
在线咨询
400-1016-218
产品详情
操作说明
注意事项
Product Information
|
Description |
Topoisomerase II alpha rabbit polyclonal |
|
Protein full name |
DNA topoisomerase 2-alpha |
|
Synonyms |
DNA topoisomerase II, alpha isozyme, TOP2A, Top-2, Top2 |
|
Immunogen |
Recombinant protein corresponding to Mouse Top2a |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
|
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Mouse, Rat |
1: 600-1: 2000 |
ovary, brain, sepsis thymus |
|
IF |
Mouse, Rat |
1: 500-1: 1000 |
ovary, brain, sepsis thymus |
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia telangiectasia.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse ovary using Top2a (GB111031) at dilution of 1: 1200 |
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Immunohistochemistry analysis of paraffin-embedded mouse brain using Top2a (GB111031) at dilution of 1: 1200 |
|
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Immunohistochemistry analysis of paraffin-embedded rat ovary using Top2a (GB111031) at dilution of 1: 1200 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using Top2a (GB111031) at dilution of 1: 1200 |
|
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Immunohistochemistry analysis of paraffin-embedded rat sepsis thymus using Top2a (GB111031) at dilution of 1: 1200 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室