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Anti -KMT1B / SUV39H2 Rabbit pAb
价格：
在线咨询
货号：
DRF101174
产品规格：
100 μL
Applications：
IHC/IF
Species：
H/M/R,H/M/R
购买数量：
在线咨询
400-1016-218
产品详情
操作说明
注意事项
Product Information
|
Description |
SUV39H2 rabbit polyclonal |
|
Protein full name |
Histone-lysine N-methyltransferase SUV39H2 |
|
Synonyms |
Histone H3-K9 methyltransferase 2, KMT1B, H3-K9-HMTase 2, Lysine N-methyltransferase 1B, Suppressor of variegation 3-9 homolog 2, Su(var)3-9 homolog 2, SUV39H2 |
|
Immunogen |
Recombinant protein corresponding to Mouse SUV39H2 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
|
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Human, Mouse, Rat |
1: 1000-1: 4000 |
breast cancer |
|
IF |
Human, Mouse, Rat |
1: 500-1: 3000 |
breast cancer |
Background
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.
Images
|
|
Immunohistochemistry analysis of paraffin-embedded human breast cancer using SUV39H2 (GB111054) at dilution of 1: 2000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室