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Anti -NEDD4 Rabbit pAb

价格: 在线咨询
货号:
DRF101177
产品规格:
100 μL
Applications:
WB
Species:
M/R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

NEDD4 rabbit polyclonal

Protein full name

E3 ubiquitin-protein ligase NEDD4

Synonyms

HECT-type E3 ubiquitin transferase NEDD4, Kiaa0093, Neural precursor cell expressed developmentally down-regulated protein 4,
Nedd4, Nedd4-1, Nedd4a

Immunogen

Recombinant protein corresponding to

Mouse NEDD4

Isotype

IgG

Purity

Affinity purification

Predicted MW.

103 kDa

Observed MW.

120 kDa

Uniprot ID

P46935, Q62940




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

brain, lung,

cerebral cortex




Background


The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/kDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.




Images


Western blot analysis of NEDD4 (GB111057) at dilution of 1: 1000

Lane 1: NIH/3T3 cell lysate
Lane 2: Mouse brain tissue lysate
Lane 3: Mouse cerebral cortex tissue lysate
Lane 4: Mouse lung tissue lysate
Lane 5: Rat brain tissue lysate
Lane 6: Rat cerebral cortex tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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