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Anti -S100 alpha 6/PRA Rabbit pAb

价格: 在线咨询
货号:
DRF101200
产品规格:
100 μL
Applications:
IHC/IF
Species:
H/M/R,H/M/R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

S100A6 rabbit polyclonal

Protein full name

Protein S100-A6

Synonyms

5B10, Calcyclin, Prolactin receptor-associated protein, S100 calcium-binding protein A6, S100a6, Cacy

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse S100A6

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane, Cytoplasm, Nucleus

Uniprot ID

P14069, P05964




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human, Mouse, Rat

1: 1000-1: 2000

colon, testis, skin

IF

Human, Mouse, Rat

1: 800-1: 2000

colon cancer, small intestine, lung, testis, skin




Background


Calcyclin, also known as Protein S100-A6, growth factor-inducible protein 2A9, S-100 calcium-binding protein A6 (S-100A6) or MLN 4, is a homodimeric member of the S-100 calcium-binding protein family whose expression is upregulated in proliferating and differentiating cells. It may function as calcium sensor and modulator, contributing to cellular calcium signaling.Calcyclin is inducible by growth factors and over expressed in acute myeloid leukemias. It is expressed in a cell-specific manner in subpopulations of neurons and astrocytes and in epithelial cells and fibroblasts. Calcyclin is a specific target of S-100B protein in vivo. The binding of Calcyclin to S-100B is stabilized by S-100B-bound calcium and zinc. Calcyclin associates with both Annexin XI and CacyBP (calcyclin-binding protein). It functions to activate several processes along the calcium signal transduction pathway including the regulation of cell growth, proliferation, secretion and exocytosis.




Images


Immunohistochemistry analysis of paraffin-embedded human colon using S100A6 (GB111078) at dilution of 1: 1000

Immunohistochemistry analysis of paraffin-embedded mouse testis using S100A6 (GB111078) at dilution of 1: 1000

Immunohistochemistry analysis of paraffin-embedded rat testis using S100A6 (GB111078) at dilution of 1: 1000

Immunohistochemistry analysis of paraffin-embedded mouse skin using S100A6 (GB111078) at dilution of 1: 1000

Immunohistochemistry analysis of paraffin-embedded rat skin using S100A6 (GB111078) at dilution of 1: 1000

Immunofluorescent analysis of paraffin-embedded human colon cancer using S100A6 (GB111078) at dilution of 1: 1000

Immunofluorescent analysis of paraffin-embedded mouse small intestine using S100A6 (GB111078) at dilution of 1: 1000

Immunofluorescent analysis of paraffin-embedded rat lung using S100A6 (GB111078) at dilution of 1: 1000

Immunofluorescent analysis of paraffin-embedded rat testis using S100A6 (GB111078) at dilution of 1: 1000

Immunofluorescent analysis of paraffin-embedded mouse skin using S100A6 (GB111078) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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