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产品详情
操作说明
注意事项
Product Information
|
Description |
PKR rabbit polyclonal |
|
Protein full name |
Interferon-induced, double-stranded RNA-activated protein kinase |
|
Synonyms |
eIF-2A protein kinase 2, Interferon-inducible RNA-dependent protein kinase, P1/eIF-2A protein kinase, Protein kinase R, Pkr, Eif2ak2, Prkr, p68 kinase, Tik, Serine/threonine-protein kinase TIK, Tyrosine-protein kinase EIF2AK2 |
|
Immunogen |
Recombinant protein corresponding to Mouse PKR |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
58 kDa |
|
Observed MW. |
62 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse |
1: 500-1: 1000 |
spleen, brain, heart |
Background
PKR is an IFN-induced serine/threonine protein kinase consisting activated by dsRNA produced during viral infections, PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth and differentiation. Upon activation, PKR gets autophosphorylated and catalyzes the phosphorylation of elF2 alpha subunit, which leads to an inhibition of protein synthesis. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival and cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, and PDGF signaling pathway. PKR has been implicated in tumor suppression and malignancy.
Images
|
|
Western blot analysis of PKR (GB111097) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室