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产品详情
操作说明
注意事项
Product Information
|
Description |
CITED4 rabbit polyclonal |
|
Protein full name |
Cbp/p300-interacting transactivator 4 |
|
Synonyms |
MSG1-related protein 2, MRG-2, Mrg2, Cited4 |
|
Immunogen |
Recombinant protein corresponding to Mouse CITED4 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
|
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Human, Mouse, Rat |
1: 1000-1: 2000 |
skeletal muscle, heart |
|
IF |
Human, Mouse, Rat |
1: 500-1: 3000 |
skeletal muscle, heart |
Background
CITED4 (CREB-binding protein/p300-interacting transactivator with E/D-rich tail 4) belongs to CITED family and all members of this family share CITED domain that can interact with CBP and p300. These proteins are transcriptional co-activators which can increase gene transcription through binding transcription factors with RNA polymerase II or via their acetyltransferase activity. CITED4 behaves as transcriptional coactivator for TFAP2/AP-2 and enhances estrogen receptors mediated transactivation. It can disrupt HIF1A -CREBBP interaction for acting as inhibitor of HIF1A mediated transactivation. CITED4 implicates in gene expression regulation during development/differentiation of blood cells, endothelial cells as well as mammary epithelial cells. CITED4 primarily localize to nucleus, however, its cytoplasmatic translocation or loss of nuclear expression has been observed in breast cancer where it is considered a prognostic marker for carcinogenesis. Moreover, in breast cancer its expression is down-regulated and often correlate with elevated HIF1A levsls, tumor growth and angiogenesis.
Images
|
|
Immunohistochemistry analysis of paraffin-embedded mouse skeletal muscle using CITED4 (GB111124) at dilution of 1: 2000 |
|
|
Immunohistochemistry analysis of paraffin-embedded mouse heart using CITED4 (GB111124) at dilution of 1: 2000 |
|
|
Immunohistochemistry analysis of paraffin-embedded rat heart using CITED4 (GB111124) at dilution of 1: 2000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室