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Anti -PFKL Rabbit pAb

价格: 在线咨询
货号:
DRF101260
产品规格:
100 μL
Applications:
IHC
Species:
H
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

PFKL rabbit polyclonal

Protein full name

ATP-dependent 6-phosphofructokinase, liver type

Synonyms

ATP-PFK, PFK-L, PFK-B, PFKL, 6-phosphofructokinase type B, Phosphofructo-1-kinase isozyme B

Immunogen

Recombinant protein corresponding to Human PFKL

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm

Uniprot ID

P17858




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human

1: 1000-1: 3000

liver cancer, prostate




Background


PFKL is the Liver isozyme of PFK (Phosphofructokinase), which is a tetrameric enzyme that catalyzes a key step in glycolysis, namely the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate by ATP. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.




Images


Immunohistochemistry analysis of paraffin-embedded human liver cancer using PFKL (GB111136) at dilution of 1: 1600

Immunohistochemistry analysis of paraffin-embedded human prostate using PFKL (GB111136) at dilution of 1: 1600




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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