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Anti -MDM2 Rabbit pAb

价格: 在线咨询
货号:
DRF101286
产品规格:
100 μL
Applications:
IHC
Species:
M,R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

MDM2 rabbit polyclonal

Protein full name

E3 ubiquitin-protein ligase Mdm2

Synonyms

Double minute 2 protein, Oncoprotein Mdm2, RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse MDM2

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus, Cytoplasm

Uniprot ID

P23804




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 1000-1: 3000

lung, kidney, thymus




Background


MDM2 is a target of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Over expression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle,apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.




Images


Immunohistochemistry analysis of paraffin-embedded mouse lung using MDM2 (GB111161) at dilution of 1: 1500

Immunohistochemistry analysis of paraffin-embedded rat lung using DM2 (GB111161) at dilution of 1: 1500

Immunohistochemistry analysis of paraffin-embedded mouse kidney using MDM2 (GB111161) at dilution of 1: 1500

Immunohistochemistry analysis of paraffin-embedded rat kidney using MDM2 (GB111161) at dilution of 1: 1500

Immunohistochemistry analysis of paraffin-embedded mouse thymus using MDM2 (GB111161) at dilution of 1: 1500




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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