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Anti -CD74 Rabbit pAb

价格: 在线咨询
货号:
DRF101822
产品规格:
100 μL
Applications:
Species:
购买数量:
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产品详情 操作说明 注意事项

Product Information


Description

CD74 rabbit polyclonal

Protein full name

H-2 class II histocompatibility antigen gamma chain

Synonyms

Ia antigen-associated invariant chain, Ii, MHC class II-associated invariant chain, CD74

Immunogen

Recombinant protein corresponding to Mouse CD74

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell Membrane

Uniprot ID

P04441, P10247




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1:1000-1:4000

lymphoid, spleen, immune spleen

IF Mouse, Rat 1:500-1:1000




Background


CD74, also known as the MHC class II associated invariant chain (Ii), is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is produced in molar excess over MHC class II and some of this is expressed by an unknown pathway on the cell surface independent of or in association with MHC class II molecules. The half life of CD74 on the cell surface is only 3 to 4 min after which it is internalized. It has been proposed that cell surface CD74 binds MHC class II molecules which have lost their antigenic peptide leading to internalization and reloading with antigenic peptide. The transport route of class II alpha/beta/Ii complexes is regulated selectively by two forms of CD74 (p33 and p35) which are generated by the use of alternative translation initiation sites. CD74 is expressed primarily by antigen presenting cells such as B lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages and monocytes together, with many epithelial cells.




Images


Immunohistochemistry analysis of paraffin-embedded mouse spleen using CD74 (GB111179) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded mouse immune spleen using CD74 (GB111179) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded mouse lymphoid using CD74 (GB111179) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded rat lymphoid using CD74 (GB111179) at dilution of 1: 2000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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