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产品详情
操作说明
注意事项
Product Information
|
Description |
CD14 rabbit polyclonal |
|
Protein full name |
Monocyte differentiation antigen CD14 |
|
Synonyms |
CD14, entrez:929, CD14 molecule |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse CD14 |
|
Isotype |
IgG |
|
Predicted MW. |
40 kDa |
|
Observed MW. |
45 kDa |
|
Purity |
Affinity purification |
|
Subcellular location |
|
|
Uniprot ID |
Applications
|
applications |
species |
dilution |
Positive tissue |
|
WB |
Human, Mouse, Rat |
1:500-1:1000 |
spleen, thymus gland |
|
IHC |
Human, Mouse, Rat |
1:500-1:1000 |
tonsil, Inflammatory lung |
Background
Coreceptor for bacterial lipopolysaccharide . In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL-.
Images
|
|
Western blot analysis of CD14(GB11254) at dilution of 1:1000. Lane 1:Raw264.7 cell lysate Lane 2:Jurkat cell lysate Lane 3:Mouse spleen tissue lysate Lane 4:Mouse thymus gland tissue lysate Lane 5:Rat spleen tissue lysate Lane 6:Rat thymus gland tissue lysate Lane7:Rat lymph node tissue lysate |
|
|
Immunohistochemistry analysis of paraffin-embedded mouse lung using CD14(GB11254) at dilution of 1:1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
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地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室