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产品详情
操作说明
注意事项
Product Information
|
Description |
SOCS1 rabbit polyclonal |
|
Protein full name |
Suppressor of cytokine signaling 1 |
|
Synonyms |
SOCS1, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, suppressor of cytokine signaling 1, TIP-3 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse SOCS1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus, Cytoplasm |
|
Uniprot ID |
Applications
|
applications |
species |
dilution |
Positive tissue |
|
IHC |
Human, Mouse, Rat |
1: 500-1: 1500 |
spleen, uters, kidney |
|
IF |
Human, Mouse, Rat |
1: 500-1: 1000 |
spleen, uters, kidney |
Background
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Images
|
Immunohistochemistry analysis of paraffin-embedded mouse spleen using SOCS1 (GB11372) at dilution of 1:900. |
|
Immunohistochemistry analysis of paraffin-embedded mouse uters using SOCS1 (GB11372) at dilution of 1:900. |
|
Immunohistochemistry analysis of paraffin-embedded rat kidney using SOCS1 (GB11372) at dilution of 1:900. |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室