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产品详情
操作说明
注意事项
Product Information
|
Description |
CD146 rabbit polyclonal |
|
Protein full name |
Cell surface glycoprotein MUC18 |
|
Synonyms |
Gicerin, Melanoma cell adhesion molecule, Melanoma-associated antigen MUC18, CD146, Muc18, Mcam, MelCAM, Sendo1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse CD146 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
72 kDa |
|
Observed MW. |
120 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
blood vessels, uterus, stomach |
Background
MCAM is an immunoglobulin super family member originally described as a cell surface adhesion protein and marker of the progression and metastasis of melanoma . Expression of MCAM protein is seen in vascular endothelial cells, activated T lymphocytes, smooth muscle, and bone marrow stromal cells. Research studies demonstrate increased MCAM expression in endothelial cells from angiogenesis-related disorders, including inflammatorybowel disease, Crohn’s disease, rheumatoid arthritis, tumors, and chronic renal failure. MCAM-expressing human mesenchymal stromal cells in the hematopoietic microenvironment are responsible for maintaining the self-renewal of hematopoietic stem and progenitor cells through direct contact between hMSC and those cells .
Images
|
Western blot analysis of CD146 (GB11955) at dilution of 1: 1000 Lane 1: HMVEC cell lysate Lane 2: HUVEC cell lysate Lane 3: A375 cell lysate Lane 4: Mouse blood vessels tissue lysate Lane 5: Mouse uterus tissue lysate Lane 6: Mouse stomach tissue lysate Lane 7: Rat blood vessels tissue lysate Lane 8: Rat uterus tissue lysate Lane 9: Rat stomach tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室